Description

1,2-Ethanediol,1-[(3R,4S)-4-Hydroxy-3-Pyrrolidinyl]-,(1S)-Rel-(9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced organic synthesis. Its precise molecular architecture makes it a valuable intermediate for constructing complex, biologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value compounds requiring specific stereochemistry.
• Bioconjugation & Probe Development: Potential use in modifying biomolecules or creating labeled probes for biochemical and diagnostic applications due to its functional groups.

Basic Information

Product Name	1,2-Ethanediol,1-[(3R,4S)-4-Hydroxy-3-Pyrrolidinyl]-,(1S)-Rel-(9Ci)
CAS No.	779337-54-1
Molecular Formula	C6H13NO3
Molecular Weight	147.17 g/mol
Synonyms	(1S)-1-[(3R,4S)-4-Hydroxypyrrolidin-3-yl]ethane-1,2-diol; (3R,4S)-3-(1,2-Dihydroxyethyl)-4-hydroxypyrrolidine; Rel-(1S,3R,4S)-3-(1,2-Dihydroxyethyl)-4-hydroxypyrrolidine; Pyrrolidine-3,4-diol, 3-(1,2-dihydroxyethyl)-, (3R,4S)-rel-(1S)-; Chiral Pyrrolidinol Ethylene Glycol Derivative; 779337-54-1; CAS 779337-54-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and optical rotation to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.