Description

5-Carboxylthiophene-2-Boronic Acid Pinacol Ester is a high-value, multifunctional heterocyclic building block designed for advanced organic synthesis. Its core value lies in the simultaneous presence of a protected boronic acid group and a carboxylic acid moiety, enabling sequential and orthogonal cross-coupling and derivatization reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for constructing complex thiophene-based scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to create advanced thiophene-containing molecules for new pesticides and herbicides with improved efficacy and selectivity.
• Material Science Research: Serves as a monomer or building block for developing conjugated polymers and organic electronic materials like OLEDs and OFETs.
• Ligand and Catalyst Development: The carboxylic acid group allows for the creation of complex chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and molecular tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Carboxylthiophene-2-Boronic Acid Pinacol Ester
CAS No.	779335-05-6
Molecular Formula	C12H15BO4S
Molecular Weight	266.12 g/mol
Synonyms	2-(5-Carboxythiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Carboxythiophene-2-boronic acid pinacol ester; Thiophene-5-carboxylic acid, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-5-carboxylic acid; 5-Carboxy-2-thienylboronic acid pinacol ester; 779335-05-6; 2-Thiophenecarboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
EINECS	Contact for details

Quality Control

Every batch of 5-Carboxylthiophene-2-Boronic Acid Pinacol Ester is produced and tested under strict quality management systems. We ensure compliance with the high-purity standards required for research and commercial-scale pharmaceutical applications. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to guarantee identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.