Description

2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Phenol is a high-value organoboron building block, specifically a boronic ester derivative of a trifluoromethyl-substituted phenol. This compound matters for its role as a critical intermediate in modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those incorporating the bioisosteric trifluoromethyl group.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the phenol-boronate moiety enables efficient scaffold diversification.
• Liquid Crystal & OLED Materials: Serves as a building block for creating advanced organic electronic materials and liquid crystal compounds requiring specific aromatic and fluorinated components.
• Polymer & Resin Modification: Employed to introduce phenol and boronate functional groups into polymer backbones, altering properties like adhesion, thermal stability, or cross-linking behavior.
• Chemical Research & Development: Essential for academic and industrial research labs exploring new synthetic methodologies and creating libraries of compounds for screening.
• Fluorinated Compound Synthesis: Acts as a versatile reagent for the controlled introduction of the 4-(trifluoromethyl)phenol fragment into more complex molecular architectures.

Basic Information

Product Name	2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Phenol
CAS No.	779331-13-4
Molecular Formula	C13H16BF3O3
Molecular Weight	288.07 g/mol
Synonyms	4-(Trifluoromethyl)phenylboronic acid pinacol ester; 2-(4-(Trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [4-(Trifluoromethyl)phenyl]boronic acid pinacol ester; 4-(Trifluoromethyl)benzeneboronic acid pinacol ester; 4-(Trifluoromethyl)phenylboronic acid, pinacol ester; 2-(4-(Trifluoromethyl)phenyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-; 4-(Trifluoromethyl)benzeneboronic acid, 1,3,2-dioxaborolane deriv.
EINECS	Contact for details

Quality Control

Our production of 2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-4-(Trifluoromethyl)Phenol adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance in sensitive cross-coupling applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.