Description

tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate is a high-purity, protected indole boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly for creating diverse indole-based scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those containing functionalized indole cores for oncology, CNS, and antiviral applications.
• Agrochemical Research: Used to construct complex molecules for developing new herbicides, fungicides, and insecticides with improved efficacy.
• Material Science: Building block for creating advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, via palladium-catalyzed coupling.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents to study biological systems.
• Academic & Contract Research: A versatile reagent for methodology development and library synthesis in academic laboratories and CROs (Contract Research Organizations).
• Scale-up Synthesis: Suitable for process development and pilot-scale manufacturing of target molecules due to its stability and reactivity profile.

Basic Information

Product Name	tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate
CAS No.	777061-38-8
Molecular Formula	C19H26BNO4
Molecular Weight	343.23 g/mol
Synonyms	1H-Indole-1-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 1,1-dimethylethyl ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole-1-carboxylate; 1-Boc-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indole; 6-Bpin-1-Boc-indole; BOC-6-BPin-indole
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Assay	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.