Description

2-Propenenitrile, 3-(4-Fluorophenyl)-3-Hydroxy- (9Ci) is a specialized fluorinated nitrile derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its core value lies in enabling the construction of complex molecular architectures, particularly for active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity compound is essential for research and development chemists and process scale-up teams in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Building block for developing advanced herbicides and fungicides with fluorinated active ingredients for enhanced efficacy.
• Fine Chemical Production: Used in the multi-step synthesis of complex fluorinated compounds for specialty materials and electronics.
• Academic & Contract Research: Serves as a valuable reagent in methodological research and process chemistry development within R&D laboratories.
• Ligand and Catalyst Development: Potential precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	2-Propenenitrile, 3-(4-Fluorophenyl)-3-Hydroxy- (9Ci)
CAS No.	776999-46-3
Molecular Formula	C9H6FNO
Molecular Weight	163.15 g/mol
Synonyms	3-(4-Fluorophenyl)-3-hydroxyacrylonitrile; (E/Z)-3-(4-Fluorophenyl)-3-hydroxy-2-propenenitrile; 4-Fluoro-β-hydroxycinnamonitrile; 3-Hydroxy-3-(4-fluorophenyl)acrylonitrile; 2-Propenenitrile, 3-(4-fluorophenyl)-3-hydroxy-; β-Hydroxy-4-fluorocinnamonitrile
EINECS	Contact for details

Quality Control

Our production of 2-Propenenitrile, 3-(4-Fluorophenyl)-3-Hydroxy- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets exacting standards for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (Specific enantiomer available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.