Description

Ethyl-2-Fluoro-5-Iodobenzoate is a high-purity fluorinated and iodinated benzoate ester, serving as a versatile and critical building block in advanced organic synthesis. Its unique halogenated structure makes it an essential intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily targeted at R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and iodine motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic compounds used in electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira, Negishi) to form biaryl and other complex structures.
• Fluorine Chemistry Research: An important reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in organic molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of client-specific target molecules.

Basic Information

Product Name	Ethyl-2-Fluoro-5-Iodobenzoate
CAS No.	773136-66-6
Molecular Formula	C9H8FIO2
Molecular Weight	294.06 g/mol
Synonyms	Ethyl 2-Fluoro-5-iodobenzoate; 2-Fluoro-5-iodobenzoic Acid Ethyl Ester; Benzoic acid, 2-fluoro-5-iodo-, ethyl ester; 5-Iodo-2-fluorobenzoic Acid Ethyl Ester; Ethyl 5-Iodo-2-fluorobenzoate; 773136-66-6; Ethyl 2-Fluoro-5-iodobenzoate CAS 773136-66-6
EINECS	Contact for details

Quality Control

Every batch of Ethyl-2-Fluoro-5-Iodobenzoate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes comprehensive analysis by HPLC, GC, NMR (1H, 13C, 19F), and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.