Description

3-Amino-3-(4-Hydroxy-3-Trifluoromethyl-Phenyl)-Propionic Acid is a specialized trifluoromethylated aromatic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group, an amino acid backbone, and a trifluoromethyl substituent, makes it a valuable intermediate for creating molecules with enhanced metabolic stability and bioavailability. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular properties.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of novel drug candidates, especially in oncology, CNS, and anti-inflammatory therapies.
• Protease Inhibitor Synthesis: Used in constructing peptide mimetics and inhibitors where the trifluoromethyl group modulates potency and selectivity.
• Agrochemical Research: Serves as a precursor for developing advanced herbicides and pesticides with improved environmental profiles.
• Material Science: Potential monomer or additive for specialty polymers where fluorine incorporation enhances chemical resistance and surface properties.
• Bioconjugation & Probe Development: Useful in creating fluorescent probes or affinity labels for biochemical and diagnostic applications.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in fluorine chemistry and asymmetric synthesis.

Basic Information

Product Name	3-Amino-3-(4-Hydroxy-3-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	773117-55-8
Molecular Formula	C10H10F3NO3
Molecular Weight	249.19 g/mol
Synonyms	3-Amino-3-[4-hydroxy-3-(trifluoromethyl)phenyl]propanoic acid; β-Amino-β-(4-hydroxy-3-trifluoromethylphenyl)propionic acid; (3R/S)-3-Amino-3-(4-hydroxy-3-trifluoromethylphenyl)propionic acid; 4-Hydroxy-3-trifluoromethyl-β-phenyl-β-alanine; 3-(4-Hydroxy-3-(trifluoromethyl)phenyl)-3-aminopropanoic acid; ATFPPA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 3-Amino-3-(4-Hydroxy-3-Trifluoromethyl-Phenyl)-Propionic Acid adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis, and NMR/IR for structural confirmation, to ensure consistency and compliance with customer specifications. Certificates of Analysis (COA) documenting all critical parameters are available upon request. We support development and cGMP-grade production for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.