Description

2-(4-Chloro-2-Fluorophenyl)-1,3-Dioxolane is a high-value fluorinated aromatic building block and protecting group reagent, essential for advanced organic synthesis. Its core value lies in enabling precise molecular construction, particularly in the development of complex active pharmaceutical ingredients (APIs) and agrochemicals. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those requiring fluorinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the chloro-fluoro-phenyl moiety impributes specific biological activity.
• Material Science Research: Serves as a precursor for monomers or ligands in the development of specialty polymers and advanced materials.
• Academic & Industrial R&D: A versatile building block for method development and exploring new chemical spaces in medicinal and synthetic chemistry.
• Protecting Group Chemistry: The 1,3-dioxolane group can act as a protecting group for aldehydes or ketones in multi-step synthetic sequences.

Basic Information

Product Name	2-(4-Chloro-2-Fluorophenyl)-1,3-Dioxolane
CAS No.	773102-67-3
Molecular Formula	C9H8ClFO2
Molecular Weight	202.61 g/mol
Synonyms	4-Chloro-2-fluorobenzaldehyde ethylene acetal; 2-(4-Chloro-2-fluorophenyl)-1,3-dioxolane; 1,3-Dioxolane, 2-(4-chloro-2-fluorophenyl)-; 4-Chloro-2-fluoro-1,3-benzodioxole (incorrect but common misnomer); 2-(4-Chloro-2-fluorophenyl)-[1,3]dioxolane; 4-Chloro-2-fluorobenzaldehyde cyclic ethylene acetal; Benzaldehyde, 4-chloro-2-fluoro-, cyclic ethylene acetal
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-2-Fluorophenyl)-1,3-Dioxolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.