Description

1-((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Methyl-3-(4-Nitrophenyl)-2,3-Dihydrofuran-2-Yl)Ethanone is a high-purity, structurally complex fluorinated organic intermediate. This compound matters for its role as a critical building block in advanced pharmaceutical and agrochemical synthesis, where its unique perfluorinated sulfonyl moiety and chiral centers enable the development of novel active ingredients. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating new molecules with enhanced properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Serves as a monomer or additive for creating specialty polymers with unique surface properties, such as oil and water repellency.
• Liquid Crystal & OLED Development: Potential building block for fluorinated components in electronic display materials.
• Catalyst Ligand Synthesis: Used to create sophisticated, fluorinated ligands for asymmetric catalysis.
• Proteolysis-Targeting Chimera (PROTAC) Development: A valuable component in the design of bifunctional molecules for targeted protein degradation.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CMOs for client-specific research and scale-up projects.
• Academic & Institutional Research: Utilized in universities and research institutes for exploratory chemistry and method development.

Basic Information

Product Name	1-((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Methyl-3-(4-Nitrophenyl)-2,3-Dihydrofuran-2-Yl)Ethanone
CAS No.	771491-74-8
Molecular Formula	C₁₇H₁₂ClF₈NO₆S
Molecular Weight	545.78 g/mol
Synonyms	1-[(2S,3R)-4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5-methyl-3-(4-nitrophenyl)-2,3-dihydro-2-furanyl]ethanone; (2S,3R)-2-Acetyl-4-[(4-chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5-methyl-3-(4-nitrophenyl)-2,3-dihydrofuran; CAS 771491-74-8; Fluorinated Dihydrofuran Sulfone Intermediate; 4-Nitrophenyl-Substituted Fluorobutylsulfonyl Furan Acetone Derivative
EINECS	Contact for details

Quality Control

Our 1-((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Methyl-3-(4-Nitrophenyl)-2,3-Dihydrofuran-2-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its complex structure, prolonged storage should be under inert atmosphere (e.g., nitrogen or argon) for optimal stability. Keep container tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.