Description

1-((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Methyl-3-Phenyl-2,3-Dihydrofuran-2-Yl)Ethanone is a sophisticated chiral fluorinated building block designed for advanced synthetic chemistry. This compound is valued for its unique structural features, including a perfluorinated alkyl chain and a sulfonyl group, which impart specific electronic and steric properties critical for developing high-performance materials and active pharmaceutical ingredients. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, where the fluorinated sulfonyl moiety can contribute to improved pesticidal activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where its structure aids in tuning electronic properties.
• Polymer Science: Employed in the creation of specialty polymers and coatings, introducing fluorine to enhance chemical resistance, thermal stability, and surface properties.
• Catalyst & Ligand Development: Acts as a scaffold for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, exploring new C-F and C-S bond-forming reactions.

Basic Information

Product Name	1-((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-5-Methyl-3-Phenyl-2,3-Dihydrofuran-2-Yl)Ethanone
CAS No.	771491-68-0
Molecular Formula	C₁₇H₁₄ClF₈O₄S
Molecular Weight	522.79 g/mol
Synonyms	(2S,3R)-1-[4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-5-methyl-3-phenyl-2,3-dihydrofuran-2-yl]ethanone; 1-[(2S,3R)-4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutane-1-sulfonyl)]-5-methyl-3-phenyl-2,3-dihydrofuran-2-yl]ethan-1-one; CAS 771491-68-0; Fluorinated Dihydrofuranone Sulfone; Chiral Fluorinated Sulfone Building Block.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Identity and purity are confirmed through a suite of analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.