Description

((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-3-(4-Methoxyphenyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone is a sophisticated chiral fluorinated organic building block of significant interest in advanced synthetic chemistry. Its complex molecular architecture, featuring a dihydrofuran core, multiple aromatic systems, and a perfluorinated sulfonyl moiety, makes it a high-value intermediate for constructing molecules with specific three-dimensional shapes and unique physicochemical properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors who require high-purity, structurally complex intermediates for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, or metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, or insecticides, where the fluorinated and sulfonyl groups can enhance bioavailability, stability, and target specificity.
• Material Science Exploration: Acts as a monomer or functional additive in the development of specialty polymers, liquid crystals, or organic electronic materials due to its aromatic and fluorinated components.
• Asymmetric Synthesis Catalyst/ Ligand Precursor: The chiral dihydrofuran structure can be utilized to develop novel ligands or organocatalysts for stereoselective transformations.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes to study enzyme function or biological pathways, leveraging its potential for specific interactions.

Basic Information

Item	Details
Product Name	((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-3-(4-Methoxyphenyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone
CAS No.	771491-34-0
Molecular Formula	C28H19ClF8O5S
Molecular Weight	639.95 g/mol
Synonyms	(2S,3R)-4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-3-(4-methoxyphenyl)-5-phenyl-2,3-dihydro-2-furanyl phenylmethanone; (2S,3R)-4-(4-Chloro-octafluorobutanesulfonyl)-3-(4-methoxyphenyl)-5-phenyl-2,3-dihydrofuran-2-yl phenyl ketone; 771491-34-0; Chiral fluorinated dihydrofuran sulfone; Phenyl[(2S,3R)-3-(4-methoxyphenyl)-5-phenyl-4-[[(1,1,2,2,3,3,4,4-octafluoro-4-chlorobutyl)sulfonyl]methyl]-2-furanyl]methanone
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for this advanced intermediate. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our production and quality control processes are designed to support cGMP compliance for pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.