Description

((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-3-(4-Nitrophenyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone is a high-value, structurally complex organic intermediate featuring a unique combination of fluorinated, sulfonyl, and aromatic moieties. This compound is critical for advanced research and development in pharmaceutical chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) with targeted properties. It serves as a sophisticated building block for medicinal chemists and process development scientists working in pharmaceutical R&D, agrochemical innovation, and specialty materials science.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the discovery and production of advanced pesticides and herbicides, leveraging its fluorinated structure for enhanced biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials due to its complex aromatic and sulfone architecture.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Catalyst Ligand Development: Potential use as a sophisticated ligand precursor in asymmetric catalysis for creating other high-value chiral compounds.
• Custom Synthesis & Contract Manufacturing: A critical component for fine chemical manufacturers offering bespoke synthesis services to the life sciences industry.

Basic Information

Product Name	((2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-Octafluorobutylsulfonyl)-3-(4-Nitrophenyl)-5-Phenyl-2,3-Dihydrofuran-2-Yl)(Phenyl)Methanone
CAS No.	771491-25-9
Molecular Formula	C27H15ClF8NO6S
Molecular Weight	662.91 g/mol
Synonyms	(2S,3R)-4-[(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutyl)sulfonyl]-3-(4-nitrophenyl)-5-phenyl-2,3-dihydro-2-furanyl phenyl methanone; (2S,3R)-4-(4-Chlorooctafluorobutanesulfonyl)-3-(4-nitrophenyl)-5-phenyl-2,3-dihydrofuran-2-yl(phenyl)methanone; Phenyl[(2S,3R)-4-[(4-chlorooctafluorobutyl)sulfonyl]-3-(4-nitrophenyl)-5-phenyl-2,3-dihydro-2-furanyl]methanone; CAS 771491-25-9; (2S,3R)-4-(4-Chloro-1,1,2,2,3,3,4,4-octafluorobutylsulfonyl)-3-(4-nitrophenyl)-5-phenyl-2,3-dihydrofuran-2-yl(phenyl)methanone.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity essential for sensitive R&D and scale-up processes. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its properties as a strong oxidizer, store separately from reducing agents, combustible materials, and other incompatible substances. Handle and store under an inert atmosphere if specified for the specific batch.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.