Description

1-Naphthalenecarbonitrile, 5,6,7,8-Tetrahydro-2,5-Dihydroxy-6-(Methylamino)-, trans- (9Ci) is a complex, multi-functional organic compound featuring a tetrahydro-naphthalene core with hydroxyl, nitrile, and methylamino substituents. This unique structure makes it a valuable advanced pharmaceutical intermediate (API intermediate) and a versatile building block for organic synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active compounds.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly those targeting neurological or cardiovascular pathways.
• Organic Synthesis Reagent: Used as a versatile precursor for constructing polycyclic frameworks and introducing functional groups in medicinal chemistry research.
• Agrochemical Research: Acts as a key intermediate in the development of new pesticides or herbicides due to its bioactive scaffold.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development and quality control in regulatory submissions.
• Ligand Synthesis: Potential use in the preparation of specialized ligands for catalysis or metal-organic frameworks (MOFs).
• Academic & Institutional Research: Utilized in universities and research institutes for studying structure-activity relationships (SAR) and novel synthetic methodologies.

Basic Information

Product Name	1-Naphthalenecarbonitrile, 5,6,7,8-Tetrahydro-2,5-Dihydroxy-6-(Methylamino)-, trans- (9Ci)
CAS No.	770653-44-6
Molecular Formula	C₁₃H₁₆N₂O₂
Molecular Weight	232.28 g/mol
Synonyms	trans-5,6,7,8-Tetrahydro-2,5-dihydroxy-6-(methylamino)-1-naphthalenecarbonitrile; (trans)-6-(Methylamino)-5,6,7,8-tetrahydro-2,5-dihydroxy-1-naphthonitrile; 2,5-Dihydroxy-6-(methylamino)-1,2,3,4,5,6,7,8-octahydronaphthalene-1-carbonitrile; 770653-44-6; 1-Naphthalenecarbonitrile, 5,6,7,8-tetrahydro-2,5-dihydroxy-6-(methylamino)-, (5R,6S)-rel-; A potential intermediate for P7C3 analogs.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements, from research to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.