Description

[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Acetic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected carboxylic acid group and a pinacol boronate ester moiety. This compound is a critical building block in modern synthetic chemistry, enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and metabolic disease research.
• Suzuki-Miyaura Cross-Coupling: Essential boronic ester reagent for constructing biaryl and heterobiaryl scaffolds in medicinal chemistry.
• Agrochemical Synthesis: Building block for creating novel herbicides, fungicides, and plant growth regulators with complex aromatic backbones.
• Material Science Research: Used in the development of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Enables the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP conditions.

Basic Information

Product Name	[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Acetic Acid tert-Butyl Ester
CAS No.	769968-18-5
Molecular Formula	C18H27BO5
Molecular Weight	334.22 g/mol
Synonyms	tert-Butyl [3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetate; 3-(Pinacolboryl)phenoxyacetic Acid tert-Butyl Ester; 2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetic Acid 1,1-Dimethylethyl Ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxyacetic Acid tert-Butyl Ester; 769968-18-5; BRN 9089605
EINECS	Contact for details

Quality Control

Our [3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Phenoxy]-Acetic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.