Description

4-Chloro-2-Fluorophenylboronic Acid, Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for drug discovery and fine chemical synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, particularly those requiring substituted biphenyl or heterobiaryl motifs.
• Agrochemical Synthesis: Employed in creating advanced herbicides, fungicides, and insecticides with specific activity profiles.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and material science.
• Organic Electronic Materials: A building block for conjugated polymers and small molecules used in OLEDs, OFETs, and other optoelectronic devices.
• Chemical Biology Probes: Useful in the synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	4-Chloro-2-Fluorophenylboronic Acid, Pinacol Ester
CAS No.	765917-27-9
Molecular Formula	C12H15BClFO2
Molecular Weight	255.51 g/mol
Synonyms	4-Chloro-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-4-chlorophenylboronic acid pinacol ester; (4-Chloro-2-fluorophenyl)boronic acid pinacol ester; 4-Chloro-2-fluorobenzeneboronic acid pinacol ester; Pinacol (4-chloro-2-fluorophenyl)boronate; 1,3,2-Dioxaborolane, 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-; B-(4-Chloro-2-fluorophenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-2-Fluorophenylboronic Acid, Pinacol Ester is produced and tested under a strict quality management system. We ensure high lot-to-lot consistency through comprehensive analytical techniques including NMR, HPLC, and GC. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.