Description

3-Amino-4-Hydroxyphenylboronic Acid Pinacol Ester is a protected boronic acid derivative that serves as a crucial synthetic intermediate in modern organic chemistry. Its value lies in the dual functionality of the boronate ester group and the reactive amine/phenol substituents, enabling precise cross-coupling and functionalization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors, particularly for constructing complex molecules in drug discovery and developing novel sensors.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Used as a stable, protected boronic acid reagent for palladium-catalyzed carbon-carbon bond formation to create biaryl structures.
• Protease Inhibitor Development: Serves as a core scaffold in the research and production of protease inhibitors for treating various diseases.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Advanced Material Synthesis: Intermediate for creating organic electronic materials, liquid crystals, and metal-organic frameworks (MOFs).
• Sensor Development: Building block for fluorescent or electrochemical sensors due to its boronate ester's affinity for diols and the modifiable aromatic core.

Basic Information

Product Name	3-Amino-4-Hydroxyphenylboronic Acid Pinacol Ester
CAS No.	760990-10-1
Molecular Formula	C₁₂H₁₈BNO₃
Molecular Weight	235.09 g/mol
Synonyms	(3-Amino-4-hydroxyphenyl)boronic acid pinacol ester; 4-Hydroxy-3-aminophenylboronic acid pinacol ester; Pinacol (3-Amino-4-hydroxyphenyl)boronate; 3-Amino-4-hydroxybenzeneboronic acid pinacol ester; B-(3-Amino-4-hydroxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 760990-10-1; Boronic acid, B-(3-amino-4-hydroxyphenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Amino-4-Hydroxyphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.