Description

4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-4-Ol is a high-purity, functionalized biphenyl derivative featuring a pinacol boronate ester group and a phenolic hydroxyl group. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile Suzuki-Miyaura cross-coupling building block for constructing complex biaryl systems. It is essential for R&D and production in the pharmaceutical, agrochemical, and materials science industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biphenyl backbones.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials and host materials in display and lighting technologies.
• Liquid Crystal Materials: A valuable intermediate for creating advanced liquid crystal compounds used in display applications.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing specialty polymers with tailored thermal and optical properties.
• Material Science Research: Employed in the development of organic semiconductors, metal-organic frameworks (MOFs), and other functional materials.
• Chemical Biology & Proteomics: Used as a probe or linker in bioconjugation chemistry and target identification studies.

Basic Information

Product Name	4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-4-Ol
CAS No.	760989-91-1
Molecular Formula	C18H21BO3
Molecular Weight	296.17 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1'-biphenyl]-4'-ol; [1,1'-Biphenyl]-4-ol, 4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4'-Hydroxybiphenyl-4-boronic acid pinacol ester; 4-(4-Hydroxyphenyl)phenylboronic acid pinacol ester; 4'-Pinacolatoboryl-[1,1'-biphenyl]-4-ol; 4-(4-Pinacolatoborylphenyl)phenol; Biphenyl-4-boronic acid, 4'-hydroxy-, pinacol ester
EINECS	Contact for details

Quality Control

Our 4'-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Biphenyl-4-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting compliance with cGMP and ICH Q7 guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.