Description

1-Cyclopropyl-4,4-Difluoro-Butane-1,3-Dione is a specialized fluorinated diketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring a cyclopropyl ring and difluoromethylene group, makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated heterocycles and complex scaffolds in drug discovery programs, particularly for candidates targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the introduction of fluorine atoms can enhance biological activity, stability, and environmental profile.
• Material Science Research: Serves as a monomer or precursor for synthesizing fluorinated polymers and advanced materials with potential applications in electronics, coatings, and specialty plastics.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands and organometallic complexes for catalytic applications.
• Fluorine Chemistry Studies: A valuable substrate for academic and industrial research exploring new fluorination methodologies and the reactivity of fluorinated enolates.

Basic Information

Product Name	1-Cyclopropyl-4,4-Difluoro-Butane-1,3-Dione
CAS No.	758709-39-6
Molecular Formula	C7H8F2O2
Molecular Weight	162.14 g/mol
Synonyms	4,4-Difluoro-1-cyclopropylbutane-1,3-dione; 1-Cyclopropyl-4,4-difluorobutane-1,3-dione; 4,4-Difluoro-1-cyclopropyl-1,3-butanedione; Cyclopropanecarbonylacetone, 4,4-difluoro-; Difluorinated Cyclopropyl Diketone; C7H8F2O2; 758709-39-6
EINECS	Contact for details

Quality Control

Our 1-Cyclopropyl-4,4-Difluoro-Butane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Custom synthesis and purification to meet specific research-grade or GMP-starting material standards are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.