Description

2-Fluoro-5-(Methoxycarbonyl)Benzeneboronic Acid Pinacol Ester, 96% is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce functionalized aromatic fragments into target structures. The pinacol ester group provides enhanced stability and handling characteristics compared to the free boronic acid.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly those containing fluorinated and ester-substituted biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic components.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as monomers for conjugated polymers and small molecules for OLEDs or OFETs.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules or for synthesizing compound libraries for high-throughput screening.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Fluoro-5-(Methoxycarbonyl)Benzeneboronic Acid Pinacol Ester, 96%
CAS No.	757982-31-3
Molecular Formula	C14H18BFO4
Molecular Weight	280.10 g/mol
Synonyms	(5-(Methoxycarbonyl)-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-(methoxycarbonyl)phenylboronic acid pinacol ester; Methyl 4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester; Methyl 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate; Benzeneboronic acid, 2-fluoro-5-(methoxycarbonyl)-, 1,1-dimethylethyl ester (pinacol ester); CAS 757982-31-3.
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Methoxycarbonyl)Benzeneboronic Acid Pinacol Ester, 96% is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed using advanced techniques including NMR, HPLC, and GC to confirm identity, purity, and impurity profile. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.