Description

Cyclopropaneacetic Acid, α-Amino-2-Nitro- (9Ci) is a specialized chiral building block and advanced pharmaceutical intermediate. This compound matters for its unique cyclopropane ring structure, which is prized in medicinal chemistry for imparting metabolic stability and conformational rigidity to drug candidates. Pharmaceutical R&D and fine chemical synthesis laboratories need it for developing novel therapeutic agents, particularly in the areas of protease inhibitors and other small-molecule drugs. Its precise stereochemistry and functional groups make it a critical component for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting viral and bacterial proteases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities with enhanced biological activity.
• Peptidomimetic Development: The α-amino acid structure makes it valuable for creating peptide analogs and mimetics with improved pharmacokinetic properties.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce the cyclopropane moiety.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical component for fine chemical manufacturers offering bespoke synthesis services to the pharma and biotech industries.

Basic Information

Product Name	Cyclopropaneacetic Acid, α-Amino-2-Nitro- (9Ci)
CAS No.	757161-76-5
Molecular Formula	C5H8N2O4
Molecular Weight	160.13 g/mol
Synonyms	2-Amino-2-nitrocyclopropaneacetic acid; (1-Amino-2-nitrocyclopropyl)acetic acid; α-Amino-α-nitrocyclopropaneacetic acid; 2-Nitro-2-aminocyclopropaneacetic acid; Cyclopropaneacetic acid, 2-amino-2-nitro-; (2-Amino-2-nitrocyclopropyl)acetic acid; (Aminonitrocyclopropyl)acetic acid; 757161-76-5
EINECS	Contact for details

Quality Control

Our Cyclopropaneacetic Acid, α-Amino-2-Nitro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to guarantee consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.