Description

4-(2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Ethyl)Morpholine is a high-value, multifunctional boronic ester derivative that serves as a critical building block in advanced organic synthesis. Its molecular architecture, combining a protected boronic acid moiety with a morpholine-linked phenoxy chain, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, including herbicides and fungicides with specific targeting properties.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs and OFETs.
• Ligand and Catalyst Development: The morpholine and boronate functional groups make it useful for constructing novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of bioconjugates and molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing complex, bespoke organic molecules.

Basic Information

Product Name	4-(2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Ethyl)Morpholine
CAS No.	756520-70-4
Molecular Formula	C18H28BNO4
Molecular Weight	333.23 g/mol
Synonyms	4-[2-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl]morpholine; 2-Morpholinoethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; 3-(2-Morpholinoethoxy)phenylboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-[2-(4-morpholinyl)ethoxy]phenyl]-1,3,2-dioxaborolane; 756520-70-4; B-3-(2-Morpholinoethoxy)phenylboronic acid pinacol ester.
EINECS	Contact for details

Quality Control

Our production of 4-(2-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Ethyl)Morpholine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All material is characterized and released against comprehensive specifications, including identity confirmation by NMR and IR spectroscopy, and purity determination by HPLC. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with customer requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.