Description

4-Chloro-2-Methoxy-5-Methylbenzonitrile is a versatile benzonitrile derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique substitution pattern makes it a valuable building block for constructing complex molecules with tailored properties. This high-purity compound is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to create novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Building block for developing new herbicides, fungicides, and insecticides, leveraging its halogen and nitrile functionality.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and polar groups.
• Dye and Pigment Chemistry: Intermediate for synthesizing advanced colorants and functional dyes with specific light-absorption properties.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations for creating biaryl structures.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for probe molecule design.

Basic Information

Product Name	4-Chloro-2-Methoxy-5-Methylbenzonitrile
CAS No.	755027-31-7
Molecular Formula	C9H8ClNO
Molecular Weight	181.62 g/mol
Synonyms	5-Methyl-4-chloro-2-methoxybenzonitrile; 2-Methoxy-4-chloro-5-methylbenzonitrile; 4-Chloro-2-methoxy-5-methyl-benzonitrile; Benzonitrile, 4-chloro-2-methoxy-5-methyl-; 755027-31-7; 4-Chloro-5-methyl-2-methoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methoxy-5-Methylbenzonitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity and purity against established specifications. Certificates of Analysis (COA) documenting all test results are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.