Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Dibenzo[B,E][1,4]Diazepin-11(10H)-One is a high-value pharmaceutical intermediate and chemical building block featuring a dibenzodiazepinone core functionalized with a pinacol boronate ester group. This compound matters as a versatile synthon in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group serves as a crucial handle for forming carbon-carbon bonds with aryl/heteroaryl halides under palladium catalysis.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science: Potential precursor for organic electronic materials, such as those used in OLEDs or conductive polymers, due to its conjugated dibenzodiazepinone system.
• Chemical Biology: Employed as a probe or linker in bioconjugation chemistry and the development of chemical tools for biological study.
• Academic & Contract Research: Serves as a specialized reagent for methodological development and complex molecule synthesis in university and CRO laboratories.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Dibenzo[B,E][1,4]Diazepin-11(10H)-One
CAS No.	755027-16-8
Molecular Formula	C21H23BN2O3
Molecular Weight	362.23 g/mol
Synonyms	11-Oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-3-ylboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-11-one; 3-Dibenzodiazepinon-11-ylboronic acid pinacol ester; 5H-Dibenzo[b,e][1,4]diazepin-11(10H)-one, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; B-3-(10,11-Dihydro-5H-dibenzo[b,e][1,4]diazepin-11-on-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5H-Dibenzo[B,E][1,4]Diazepin-11(10H)-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity (HPLC), identity (NMR, IR), and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.