Description

2-(3,4-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling the efficient construction of complex molecules through Suzuki-Miyaura cross-coupling reactions, a Nobel Prize-winning methodology. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing difluorophenyl motifs, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the difluorophenyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a precursor for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand & Catalyst Development: Employed in the research and synthesis of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.
• Polymer Chemistry: Can be incorporated into polymer backbones via cross-coupling to create specialty polymers with tailored properties.

Basic Information

Product Name	2-(3,4-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	754226-39-6
Molecular Formula	C12H15BF2O2
Molecular Weight	240.06 g/mol
Synonyms	(3,4-Difluorophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(3,4-difluorophenyl)-1,3,2-dioxaborolane; 3,4-Difluorophenylboronic acid pinacol ester; Pinacol (3,4-Difluorophenyl)boronate; (3,4-Difluorophenyl)BPin; 2-(3,4-Difluorophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane; B-(3,4-Difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 2-(3,4-Difluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible cross-coupling reaction yields. Our standard quality assurance includes comprehensive analytical testing via NMR, HPLC, and GC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.