Description

2-(3,4-Difluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that incorporate difluoromethoxy phenyl motifs.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and semiconductors, where precise fluorination is required.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring this specific boronic ester.

Basic Information

Product Name	2-(3,4-Difluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	754226-38-5
Molecular Formula	C13H17BF2O3
Molecular Weight	270.09 g/mol
Synonyms	2-(3,4-Difluoro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3,4-Difluoro-5-methoxyphenyl)boronic acid pinacol ester; 3,4-Difluoro-5-methoxybenzeneboronic acid pinacol ester; 5-Methoxy-3,4-difluorophenylboronic acid pinacol ester; Pinacol (3,4-difluoro-5-methoxyphenyl)boronate; CAS 754226-38-5
EINECS	Contact for details

Quality Control

Our 2-(3,4-Difluoro-5-Methoxyphenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the stringent requirements for research and process chemistry. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management standards to guarantee reliable supply and product integrity for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.