Description

2H-Pyran-2-One, Tetrahydro-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci) is a specialized fluorinated heterocyclic compound that serves as a valuable synthetic intermediate. Its unique structure, featuring a trifluoromethylated hydroxyethylidene group fused to a tetrahydro-2H-pyran-2-one core, makes it a critical building block for introducing fluorinated motifs into target molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and environmental stability.
• Advanced Material Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated components.
• Chemical Biology & Probe Development: Serves as a scaffold for creating fluorinated molecular probes and enzyme inhibitors used in biochemical research.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of complex fluorinated molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2H-Pyran-2-One, Tetrahydro-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci)
CAS No.	750597-24-1
Molecular Formula	C7H7F3O3
Molecular Weight	196.13 g/mol
Synonyms	3-(2,2,2-Trifluoro-1-hydroxyethylidene)tetrahydro-2H-pyran-2-one; Tetrahydro-3-(2,2,2-trifluoro-1-hydroxyethylidene)-2H-pyran-2-one; 2H-Pyran-2-one, tetrahydro-3-(2,2,2-trifluoro-1-hydroxyethylidene)-; 750597-24-1; 3-(Trifluoroacetyl)tetrahydro-2H-pyran-2-one hydrate (tautomer); Fluorinated Dihydro-2H-pyranone; TFHP Intermediate
EINECS	Contact for details

Quality Control

Our 2H-Pyran-2-One, Tetrahydro-3-(2,2,2-Trifluoro-1-Hydroxyethylidene)- (9Ci) is produced under strict quality management protocols. We offer material suitable for research and development (R&D) and process scale-up, with typical purity grades of 95% to 98% (by HPLC). Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each batch. Specifications can be developed to meet specific project requirements, including custom purity grades or analytical methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.