Description

Rac-2-[(1R,2R)-2-tert-Butylcyclopropyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane, Trans is a high-purity, advanced boronic ester building block used in modern synthetic chemistry. This compound matters for its role as a key chiral intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for cross-coupling reactions like Suzuki-Miyaura couplings.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those requiring chiral cyclopropane motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile organoboron reagent for forming carbon-carbon bonds in complex molecule assembly.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the tert-butylcyclopropyl group confers specific biological activity.
• Material Science Research: Employed in the development of organic electronic materials and liquid crystals due to its stable boronic ester functionality and specific stereochemistry.
• Asymmetric Synthesis: Utilized as a chiral precursor or auxiliary in stereoselective synthesis routes.
• Chemical Biology Probes: Acts as a handle for bioconjugation or in the synthesis of molecular probes for studying biological systems.

Basic Information

Product Name	Rac-2-[(1R,2R)-2-tert-Butylcyclopropyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane, Trans
CAS No.	749885-70-9
Molecular Formula	C₁₅H₂₉BO₂
Molecular Weight	252.20 g/mol
Synonyms	trans-2-(2-tert-Butylcyclopropyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (1R,2R)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tert-butylcyclopropane; rac-(1R,2R)-2-tert-Butyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclopropane; Pinacol (1R,2R)-2-tert-butylcyclopropane-1-boronate; tert-Butylcyclopropylpinacolboronate; B-(trans-2-tert-Butylcyclopropyl)pinacolborane; Trans-2-tert-Butylcyclopropylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our Rac-2-[(1R,2R)-2-tert-Butylcyclopropyl]-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane, Trans is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹¹B, ¹³C), and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with REACH, TSCA, and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.