Description

L-2,4,5-Trifluorophe is a high-purity, non-natural amino acid derivative characterized by a trifluoromethylphenyl side chain. This compound is a critical chiral building block in modern pharmaceutical research and development, offering unique steric and electronic properties. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides with improved efficacy and selectivity.
• Peptide Mimetics: Incorporated into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands used in asymmetric catalysis.
• Chemical Biology Probes: Employed in the design of molecular probes for studying enzyme function and protein-protein interactions.
• Material Science Research: Investigated as a monomer or additive for specialty polymers with unique fluorinated properties.

Basic Information

Product Name	L-2,4,5-Trifluorophe
CAS No.	749847-57-2
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	(S)-2-Amino-3-(2,4,5-trifluorophenyl)propanoic acid; L-2,4,5-Trifluorophenylalanine; L-α-Amino-2,4,5-trifluorohydrocinnamic acid; F3Phe-OH; (S)-3-(2,4,5-Trifluorophenyl)alanine; 2,4,5-Trifluoro-L-phenylalanine; L-(2,4,5-Trifluorophenyl)alanine; 749847-57-2
EINECS	Contact for details

Quality Control

Every batch of L-2,4,5-Trifluorophe is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure compliance with high-purity standards for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.