Description

Ethanone, 2,2-Difluoro-2-Methoxy-1-(4-Methoxyphenyl)- (9Ci) is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its unique structural features, including difluoromethoxy and methoxyphenyl groups, which are valuable for modulating the physicochemical properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Fluorine Chemistry Research: An important reagent for studying the introduction of fluorine and fluorinated motifs into complex molecular architectures to improve metabolic stability and membrane permeability.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP or research-grade conditions for client projects.

Basic Information

Product Name	Ethanone, 2,2-Difluoro-2-Methoxy-1-(4-Methoxyphenyl)- (9Ci)
CAS No.	748800-50-2
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	1-(4-Methoxyphenyl)-2,2-difluoro-2-methoxyethanone; 2,2-Difluoro-2-methoxy-1-(4-methoxyphenyl)ethanone; 4-Methoxyphenyl 2,2-difluoro-2-methoxyacetyl ketone; α,α-Difluoro-α-methoxy-4-methoxyacetophenone; Difluoromethoxy(4-methoxyphenyl)methanone; (4-Methoxyphenyl)(difluoromethoxy)methanone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2-Difluoro-2-Methoxy-1-(4-Methoxyphenyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For advanced applications, we can supply material that meets research-grade or custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.