Description

1-Methyl-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]piperazine is a high-value, advanced pharmaceutical intermediate and building block featuring a piperazine core linked to a pinacol boronate ester group. This compound matters for its critical role in modern organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecules. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between its aryl boronate group and various aryl/heteroaryl halides, a cornerstone reaction in modern organic synthesis.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the piperazine moiety can impart specific biological activity.
• Material Science Precursor: Serves as a monomer or functional unit in the synthesis of organic electronic materials, such as polymers for OLEDs or conductive films.
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Ligand and Catalyst Development: The piperazine nitrogen atoms can be functionalized to create novel ligands for metal catalysis.

Basic Information

Product Name	1-Methyl-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]piperazine
CAS No.	747413-21-4
Molecular Formula	C17H27BN2O2
Molecular Weight	302.22 g/mol
Synonyms	1-Methyl-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylpiperazin-1-ylbenzene; 1-Methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; 4-(1-Methylpiperazin-4-yl)phenylboronic acid pinacol ester; 4-(N-Methylpiperazinyl)phenylboronic acid pinacol ester; 747413-21-4; 1-Methyl-4-(4-(pinacolatoboryl)phenyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl]piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.