Description

4-Chloro-3',4',5'-Trifluorobenzophenone is a high-value fluorinated benzophenone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its precise molecular architecture, featuring both chloro and trifluoro substitutions, makes it an essential building block for constructing complex, bioactive molecules. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its unique halogen pattern is instrumental in modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and lipophilicity.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with enhanced thermal and chemical resistance.
• Chemical Research & Development: A versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	4-Chloro-3',4',5'-Trifluorobenzophenone
CAS No.	746651-96-7
Molecular Formula	C14H7ClF3O
Molecular Weight	292.65 g/mol
Synonyms	4-Chloro-3,4,5-trifluorobenzophenone; (4-Chlorophenyl)(3,4,5-trifluorophenyl)methanone; 3',4',5'-Trifluoro-4-chlorobenzophenone; Benzophenone, 4-chloro-3',4',5'-trifluoro-; 746651-96-7; AKOS BRN 0975; 1-(4-Chlorophenyl)-2-(3,4,5-trifluorophenyl)ethanone (common misnomer); 4-Chloro-α,α,α-trifluoro-m-benzophenone
EINECS	Contact for details

Quality Control

Our 4-Chloro-3',4',5'-Trifluorobenzophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP, ISO, and other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.