Description

3,4'-Difluoro-2'-Methylbenzophenone is a high-purity, specialty benzophenone derivative distinguished by its specific fluorine and methyl substitution pattern. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, valued for its role in modulating the biological activity and physicochemical properties of target molecules. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams engaged in developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation herbicides and pesticides, where the difluoro and methyl groups contribute to enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated organic compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers, imparting desired characteristics like thermal stability or specific optical properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Heck) and as a scaffold for constructing complex polycyclic structures in medicinal chemistry.
• Photoinitiator Research: Investigated for potential use in UV-curable coatings, inks, and adhesives due to the benzophenone core's photoactive properties.

Basic Information

Product Name	3,4'-Difluoro-2'-Methylbenzophenone
CAS No.	746651-91-2
Molecular Formula	C14H10F2O
Molecular Weight	232.23 g/mol
Synonyms	(2-Methyl-4-fluorophenyl)(3-fluorophenyl)methanone; 3-Fluoro-2'-methyl-4'-fluorobenzophenone; 2'-Methyl-3,4'-difluorobenzophenone; Benzophenone, 3,4'-difluoro-2'-methyl-; 3,4'-Difluoro-2'-methylbenzophenone; (3-Fluorophenyl)(2-methyl-4-fluorophenyl)methanone
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols aligned with cGMP principles for pharmaceutical intermediates. Every batch of 3,4'-Difluoro-2'-Methylbenzophenone is analytically verified using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, and stability data is available to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to preserve optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.