Description

1-(4-Bromo-2,6-Difluoro-Phenyl)-Ethanone is a high-purity, halogenated aromatic ketone building block of significant importance in advanced organic synthesis. This compound matters because it provides a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals. Its defined structure and reactivity make it a critical intermediate for introducing specific bromo and difluoro substitution patterns into target molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Acts as an intermediate for electron-transport materials and host materials in OLED devices.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Chemical Research & Development: A valuable reagent for academic and industrial research in synthetic methodology development and material science.

Basic Information

Product Name	1-(4-Bromo-2,6-Difluoro-Phenyl)-Ethanone
CAS No.	746630-34-2
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	4'-Bromo-2',6'-difluoroacetophenone; 4-Bromo-2,6-difluoroacetophenone; 1-Acetyl-4-bromo-2,6-difluorobenzene; 2,6-Difluoro-4-bromoacetophenone; (4-Bromo-2,6-difluorophenyl)ethanone; Ethanone, 1-(4-bromo-2,6-difluorophenyl)-; Acetophenone, 4'-bromo-2',6'-difluoro-
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2,6-Difluoro-Phenyl)-Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.