Description

1-Boc-4-(4-Aminobutyl)Piperazine is a high-purity, protected piperazine derivative of significant importance in advanced organic synthesis. This compound serves as a critical bifunctional building block, offering both a reactive primary amine and a protected secondary amine for sequential, controlled derivatization. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), complex ligands, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Peptide Mimetics & Linker Chemistry: Used to introduce spacer arms and functional handles in the design of peptide analogs and bioconjugates.
• Ligand Synthesis for Catalysis: Employed in the preparation of sophisticated nitrogen-containing ligands for transition metal catalysis.
• Polymer Modification: Acts as a functional monomer or cross-linking agent for creating specialty polyamines and smart polymers.
• Chemical Biology Probes: Utilized in the development of molecular probes and tools for studying biological pathways.
• Scale-up & Custom Synthesis: Supplied for process development and commercial-scale manufacturing under cGMP guidelines where required.

Basic Information

Product Name	1-Boc-4-(4-Aminobutyl)Piperazine
CAS No.	745048-07-1
Molecular Formula	C13H27N3O2
Molecular Weight	257.37 g/mol
Synonyms	1-Boc-4-(4-Aminobutyl)piperazine; 4-(4-Aminobutyl)-1-(tert-butoxycarbonyl)piperazine; tert-Butyl 4-(4-aminobutyl)piperazine-1-carboxylate; 1-N-Boc-4-(4-aminobutyl)piperazine; N-Boc-4-(4-aminobutyl)piperazine; Boc-4-(4-Aminobutyl)piperazine; Piperazine, 4-(4-aminobutyl)-1-[(1,1-dimethylethoxy)carbonyl]-; 1-(tert-Butoxycarbonyl)-4-(4-aminobutyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(4-Aminobutyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.