Description

3-Bromo-2-Methyl-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolopyridine core functionalized with bromo, methyl, and phenylsulfonyl groups. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for kinase-targeted drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Organic Synthesis Building Block: The bromine atom provides a versatile handle for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Chemical Biology Probes: Serves as a scaffold for developing molecular probes to study enzyme function and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.

Basic Information

Item	Details
Product Name	3-Bromo-2-Methyl-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	744209-37-8
Molecular Formula	C₁₆H₁₃BrN₂O₂S
Molecular Weight	377.26 g/mol
Synonyms	3-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-2-methyl-1-(phenylsulfonyl)-; 3-Bromo-2-methyl-1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 3-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 744209-37-8; 3-Bromo-2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 744209-37-8)
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Methyl-1-(Phenylsulfonyl)-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We are committed to meeting the stringent requirements of GMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.