Description

2,3-Dichloropyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is critically needed by R&D and production chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyridine-based drug candidates, including kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific chlorinated pyridine motifs for enhanced bioactivity.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs) with tailored electronic properties.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura couplings to form biaryl and heterobiaryl bonds, a fundamental transformation in medicinal and process chemistry.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	2,3-Dichloropyridine-5-Boronic Acid Pinacol Ester
CAS No.	741709-64-8
Molecular Formula	C11H12BCl2NO2
Molecular Weight	272.94 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dichloropyridine; (2,3-Dichloropyridin-5-yl)boronic acid pinacol ester; 2,3-Dichloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2,3-Dichloro-5-pyridineboronic acid pinacol ester; 2,3-Dichloro-5-(pinacolboronato)pyridine; 2,3-Dichloro-5-pyridinylboronic acid pinacol ester; 2,3-Dichloro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our 2,3-Dichloropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC, and GC analysis, to confirm identity and purity. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.