Description

2-Acetylpyridine-4-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in its functional boronic ester group, which is essential for modern cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a crucial boronic ester coupling partner for creating biaryl and heterobiaryl structures central to many modern drugs and agrochemicals.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific pyridine-based scaffolds.
• Material Science & OLED Development: Employed in the synthesis of organic ligands for catalysts and in creating complex organic molecules for electronic materials and light-emitting diodes.
• Chemical Biology & Probe Development: Utilized as a precursor for creating molecular probes and tools to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Acetylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	741709-58-0
Molecular Formula	C13H18BNO3
Molecular Weight	247.10 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-acetylpyridine; 2-Acetyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Acetylpyridine-4-boronic acid pinacol ester; 2-Acetyl-4-pyridineboronic acid pinacol ester; 4-(2-Acetylpyridin-4-yl)boronic acid pinacol ester; (2-Acetylpyridin-4-yl)boronic acid pinacol ester; 741709-58-0
EINECS	Contact for details

Quality Control

Our 2-Acetylpyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical development and meet the stringent requirements of global regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.