Description

Ethyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate is a high-value boronic ester derivative, serving as a crucial synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced material synthesis. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in the development of benzofuran-based drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate the benzofuran scaffold.
• Material Science Research: Serves as a precursor for organic electronic materials, including organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: Specifically designed as a pinacol boronate ester reagent for palladium-catalyzed Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for studying biological processes.
• Academic & Industrial R&D: A vital tool for medicinal chemistry and process chemistry research in both university and corporate laboratory settings.

Basic Information

Product Name	Ethyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate
CAS No.	736989-87-0
Molecular Formula	C19H25BO5
Molecular Weight	344.21 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-benzofuran-2-carboxylic acid ethyl ester; Ethyl 5-(pinacolboryl)benzofuran-2-carboxylate; 2-Benzofurancarboxylic acid, 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, ethyl ester; Ethyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-2-carboxylate; 736989-87-0; Benzofuran-2-carboxylic acid, 5-(pinacolatoboron)-, ethyl ester.
EINECS	Contact for details

Quality Control

Our Ethyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-Benzofuran-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.