Description

1,3,2-Dioxaborolane, 2-[(1E)-2-(2,5-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl- is a high-purity, functionalized organoboron reagent. This compound is a critical synthetic intermediate, prized for its role in cross-coupling reactions, particularly the Suzuki-Miyaura coupling, which is fundamental to constructing complex molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery, chemical synthesis, and material science applications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing biaryl motifs and fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that incorporate difluorophenyl groups for enhanced biological activity and stability.
• Material Science Research: Serves as a precursor in the development of organic electronic materials, such as OLEDs and organic semiconductors, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boron reagent in palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds between aromatic rings.
• Chemical Synthesis & Process Development: Employed in medicinal chemistry and process R&D for the scalable synthesis of complex, fluorinated organic molecules.
• Ligand and Catalyst Development: Utilized as a starting material for creating novel bidentate ligands or organometallic catalysts.

Basic Information

Item	Details
Product Name	1,3,2-Dioxaborolane, 2-[(1E)-2-(2,5-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl-
CAS No.	736987-80-7
Molecular Formula	C₁₄H₁₇BFO₂
Molecular Weight	262.09 g/mol
Synonyms	2-[(E)-2-(2,5-Difluorophenyl)vinyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (E)-2-(2-(2,5-Difluorophenyl)vinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2,5-Difluorostyrylboronic Acid Pinacol Ester; trans-2-(2,5-Difluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2,5-Difluorophenyl)ethenylboronic Acid Pinacol Ester; 736987-80-7; (E)-4,4,5,5-Tetramethyl-2-(2-(2,5-difluorophenyl)vinyl)-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-[(1E)-2-(2,5-Difluorophenyl)Ethenyl]-4,4,5,5-Tetramethyl- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and commercial synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and GC analysis, to ensure compliance with customer specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥95.0% (Typical: 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.