Description

E-2-(Thiophen-3-Yl)Vinylboronic Acid Pinacol Ester is a high-value organoboron building block, specifically a vinylboronic ester derivative, widely utilized in modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce functionalized thiophene-vinyl motifs into target structures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates containing thiophene heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science: Enables the creation of conjugated polymers and organic electronic materials for applications in OLEDs and semiconductors.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	E-2-(Thiophen-3-Yl)Vinylboronic Acid Pinacol Ester
CAS No.	736987-75-0
Molecular Formula	C₁₄H₁₉BO₂S
Molecular Weight	262.17 g/mol
Synonyms	3-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)thiophene; (E)-2-(3-Thienyl)vinylboronic acid pinacol ester; 2-(Thiophen-3-yl)ethenylboronic acid pinacol ester; 3-Vinylthiophene-2-boronic acid pinacol ester; Boronic acid, B-[2-(3-thienyl)ethenyl]-, 1,1-dimethylethyl ester; 736987-75-0; Thiophene-3-vinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our E-2-(Thiophen-3-Yl)Vinylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity confirmation, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z Ratio by HPLC)	≥ 95:5 (E:Z)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.