Description

1H-Indole-1-Carboxylicacid,5-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethenyl]-,1,1-Dimethylethylester is a high-value, advanced pharmaceutical intermediate featuring a vinyl boronate ester functional group. This compound matters as a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those containing indole or substituted indole scaffolds.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds under mild conditions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science: Potential building block for organic electronic materials and functional polymers due to its conjugated system.
• Chemical Biology & Proteomics: Can be utilized in the development of molecular probes and activity-based protein profiling reagents.
• Academic & Contract Research: Essential for methodological development and exploratory synthesis in university and CRO laboratories.

Basic Information

Item	Details
Product Name	1H-Indole-1-Carboxylicacid,5-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethenyl]-,1,1-Dimethylethylester
CAS No.	736987-68-1
Molecular Formula	C21H28BNO4
Molecular Weight	369.26 g/mol
Synonyms	5-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)-1H-indole-1-carboxylic acid tert-butyl ester; tert-Butyl 5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)vinyl)-1H-indole-1-carboxylate; 5-Vinylboronic acid pinacol ester indole-1-carboxylic acid tert-butyl ester; BOC-protected 5-vinylboronate indole; 1-Boc-5-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl)indole
EINECS	Contact for details

Quality Control

Every batch of our 1H-Indole-1-Carboxylicacid,5-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Ethenyl]-,1,1-Dimethylethylester undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and process development. Our quality management system is designed to support cGMP and ISO standards for advanced intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.