Description

Cyclohexanecarboxylic Acid, 1-Fluoro-2-Hydroxy-, trans- (9Ci) is a high-purity, stereochemically defined fluorinated building block essential for advanced organic synthesis. This compound is valued for its unique structural features, combining a carboxylic acid handle with fluorine and hydroxyl substituents in a specific trans configuration on a cyclohexane ring, enabling precise molecular modifications. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for applications requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored properties for advanced materials.
• Fluorine Chemistry Studies: A valuable reference compound and starting material for academic and industrial research exploring the effects of fluorination on molecular conformation and reactivity.

Basic Information

Product Name	Cyclohexanecarboxylic Acid, 1-Fluoro-2-Hydroxy-, trans- (9Ci)
CAS No.	736906-86-8
Molecular Formula	C7H11FO3
Molecular Weight	162.16 g/mol
Synonyms	trans-1-Fluoro-2-hydroxycyclohexanecarboxylic acid; (1R,2R)-1-Fluoro-2-hydroxycyclohexanecarboxylic acid; (1S,2S)-1-Fluoro-2-hydroxycyclohexanecarboxylic acid; 1-Fluoro-2-hydroxy-cyclohexanecarboxylic acid, trans-; trans-1-Fluoro-2-hydroxycyclohexane-1-carboxylic acid; Fluorohydroxycyclohexanecarboxylic Acid; 736906-86-8
EINECS	Contact for details

Quality Control

Our Cyclohexanecarboxylic Acid, 1-Fluoro-2-Hydroxy-, trans- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.