Description

4-(4-Difluoromethoxy-Phenyl)-Butan-2-One is a high-purity, fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique difluoromethoxy-substituted phenyl structure makes it a valuable intermediate for creating novel compounds with enhanced properties. This product is primarily targeted at research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the difluoromethoxy group can improve biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in liquid crystal mixtures for advanced display technologies.
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for high-efficiency OLED devices.
• Polymer Modification: Acts as a monomer or cross-linking agent for introducing fluorine into polymer backbones to alter thermal and chemical resistance.
• Chemical Research & Development: A versatile reagent for exploring new fluorination methodologies and constructing complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	4-(4-Difluoromethoxy-Phenyl)-Butan-2-One
CAS No.	733044-93-4
Molecular Formula	C11H12F2O2
Molecular Weight	214.21 g/mol
Synonyms	1-[4-(Difluoromethoxy)phenyl]butan-2-one; 4-(Difluoromethoxyphenyl)-2-butanone; 2-Butanone, 4-[4-(difluoromethoxy)phenyl]-; DFMPB; p-Difluoromethoxyphenyl butanone; 4-(4-(Difluoromethoxy)phenyl)butan-2-one
EINECS	Contact for details

Quality Control

Our 4-(4-Difluoromethoxy-Phenyl)-Butan-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent absorption of water vapor from the atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.