Description

1-Cbz-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydropyridine is a high-value, protected boronic ester derivative, serving as a critical advanced pharmaceutical intermediate for modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on synthesizing novel drug candidates and bioactive molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex, nitrogen-containing heterocycles prevalent in active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of C-C bonds with aryl or vinyl halides, crucial for constructing complex molecular architectures.
• Medicinal Chemistry Research: Used in the discovery and optimization of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Intermediate in the development of novel pesticides and herbicides requiring specific heterocyclic scaffolds.
• Material Science Precursor: Potential use in creating organic electronic materials and ligands for catalysis.
• Process Chemistry & Scale-up: Supports the development of robust, scalable synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	1-Cbz-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydropyridine
CAS No.	731852-88-3
Molecular Formula	C19H28BNO4
Molecular Weight	345.24 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylic Acid Benzyl Ester; 1-Cbz-6-Pinacolboron-1,2,3,4-tetrahydropyridine; N-Cbz-6-BPin-1,2,3,4-tetrahydropyridine; 1,2,3,4-Tetrahydropyridine-1-carboxylic acid, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, phenylmethyl ester
EINECS	Contact for details

Quality Control

Our 1-Cbz-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1,2,3,4-Tetrahydropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.