Description

4-Benzyloxy-1-Bromo-2-Chloro-Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective further functionalization, making it a critical intermediate in the development of complex molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a substituted benzyloxy and halogenated phenyl core.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where its halogen atoms provide sites for further chemical modification.
• Ligand and Catalyst Development: Acts as a starting material for creating sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers due to its aromatic and halogenated structure.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig aminations, leveraging the bromo and chloro substituents for sequential coupling.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	4-Benzyloxy-1-Bromo-2-Chloro-Benzene
CAS No.	729590-57-2
Molecular Formula	C₁₃H₁₀BrClO
Molecular Weight	297.57 g/mol
Synonyms	1-Bromo-2-chloro-4-(phenylmethoxy)benzene; 2-Chloro-1-bromo-4-benzyloxybenzene; 4-Benzyloxy-2-chlorobromobenzene; Benzene, 1-bromo-2-chloro-4-(phenylmethoxy)-; 1-Bromo-2-chloro-4-(benzyloxy)benzene; p-Benzyloxy-o-chlorobromobenzene; (2-Chloro-4-benzyloxyphenyl)bromide
EINECS	Contact for details

Quality Control

Every batch of 4-Benzyloxy-1-Bromo-2-Chloro-Benzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.