Description

L-Proline, 4-(Fluoromethylene)-5-Oxo- (9Ci) is a specialized, high-value fluorinated proline derivative, identified by CAS NO 728034-35-3. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, offering unique reactivity for constructing complex molecular architectures. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and agrochemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel drug candidates, particularly in protease inhibitor and peptide-based therapeutic programs.
• Peptidomimetics Research: Used to introduce conformational constraints and fluorine atoms into peptide backbones to enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the synthesis of advanced, fluorinated agrochemicals with improved efficacy and environmental profiles.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes for studying enzyme mechanisms and protein-ligand interactions.
• Asymmetric Catalysis Ligand Precursor: Potential use in the development of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Research: Investigated as a monomer or building block for specialty polymers and advanced materials with unique properties.

Basic Information

Product Name	L-Proline, 4-(Fluoromethylene)-5-Oxo- (9Ci)
CAS No.	728034-35-3
Molecular Formula	C6H8FNO3
Molecular Weight	161.13 g/mol
Synonyms	4-(Fluoromethylene)-5-oxo-L-proline; (2S)-4-(Fluoromethylene)-5-oxopyrrolidine-2-carboxylic acid; 4-Fluoromethylene-5-oxo-L-proline; 4-(Fluoromethylene)-5-oxo-L-proline (9CI); Fluoromethylene-oxoproline; L-4-(Fluoromethylene)-5-oxoproline
EINECS	Contact for details

Quality Control

Every batch of L-Proline, 4-(Fluoromethylene)-5-Oxo- (9Ci) is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development projects. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results for assay (HPLC), chiral purity, and identification (IR/NMR).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.