Description

2-Bromo-1-(4-Chloro-2-Fluorophenyl)Ethanone is a high-purity, synthetically valuable halogenated aromatic ketone building block. This compound is critical for the efficient synthesis of complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those with halogenated aromatic motifs for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the bromo and fluoro substituents contribute to target specificity and environmental persistence.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals or organic semiconductors, due to its rigid, halogenated structure.
• Cross-Coupling Reactions: The bromoacetyl group is a reactive handle for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form carbon-carbon bonds.
• Heterocyclic Chemistry: Employed in the construction of complex heterocyclic scaffolds, including benzofurans, indoles, and other fused ring systems important in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	2-Bromo-1-(4-Chloro-2-Fluorophenyl)Ethanone
CAS No.	725743-41-9
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	2-Bromo-4'-Chloro-2'-Fluoroacetophenone; 4-Chloro-2-Fluorophenacyl Bromide; α-Bromo-4-Chloro-2-Fluoroacetophenone; 1-(4-Chloro-2-Fluorophenyl)-2-Bromoethanone; 2-Bromo-1-(4-Chloro-2-fluorophenyl)ethan-1-one; Bromo(4-chloro-2-fluorophenyl)methanone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(4-Chloro-2-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.