Description

2-Bromo-1-(5-Chloro-2-Fluorophenyl)Ethanone is a high-purity halogenated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, chlorine, and fluorine substituents, makes it a versatile and reactive intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogenated phenyl core.
• Material Science Research: Serves as a building block for creating novel organic materials, liquid crystals, and functional polymers.
• Cross-Coupling Reactions: The bromoacetyl group is an excellent electrophile for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck).
• Heterocyclic Chemistry: A crucial starting material for the synthesis of various nitrogen- and oxygen-containing heterocycles, which are common scaffolds in medicinal chemistry.
• Chemical Biology Probes: Used in the development of molecular probes and tags for studying biological processes.

Basic Information

Item	Details
Product Name	2-Bromo-1-(5-Chloro-2-Fluorophenyl)Ethanone
CAS No.	725743-40-8
Molecular Formula	C8H5BrClFO
Molecular Weight	251.48 g/mol
Synonyms	2-Bromo-1-(5-chloro-2-fluorophenyl)ethan-1-one; 5-Chloro-2-fluoro-α-bromoacetophenone; α-Bromo-5-chloro-2-fluoroacetophenone; 2-Bromo-5'-chloro-2'-fluoroacetophenone; 1-(5-Chloro-2-fluorophenyl)-2-bromoethanone; 2-Bromo-1-(5-chloro-2-fluorophenyl)ethanone; Bromo(5-chloro-2-fluorophenyl)methanone; (5-Chloro-2-fluorophenyl)(bromo)methanone
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(5-Chloro-2-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee batch-to-batch consistency and traceability for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.