Description

3-(N,o-Dimethylhydroxylaminocarbonyl)Phenylboronic Acid is a specialized boronic acid derivative featuring a dimethylhydroxylaminocarbonyl functional group, making it a valuable building block in modern synthetic chemistry. Its primary value lies in its dual functionality, serving as both a boronic acid for Suzuki-Miyaura cross-coupling reactions and a protected hydroxamate or precursor for Weinreb amide-like chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries who require advanced intermediates for the synthesis of complex molecules, particularly in drug discovery and development pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds requiring aryl-boronate coupling and subsequent amide bond formation.
• Suzuki-Miyaura Cross-Coupling Reagent: Used as an organoboron partner in palladium-catalyzed cross-coupling reactions to construct biaryl and heterobiaryl structures, which are common motifs in medicinal chemistry.
• Weinreb Amide Alternative/Precursor: The dimethylhydroxylaminocarbonyl group can act as a masked carboxylic acid or be transformed into ketones, aldehydes, or amides, offering versatile synthetic pathways.
• Agrochemical Synthesis: Employed in the research and production of advanced crop protection agents and herbicides that incorporate specific aryl frameworks.
• Material Science Research: Serves as a monomer or functionalization agent in the development of novel organic electronic materials and polymers.
• Chemical Biology & Proteomics: Can be utilized in the development of activity-based probes or affinity ligands that target specific enzymes or proteins.

Basic Information

Product Name	3-(N,o-Dimethylhydroxylaminocarbonyl)Phenylboronic Acid
CAS No.	723281-57-0
Molecular Formula	C9H12BNO4
Molecular Weight	209.01 g/mol
Synonyms	(3-((Dimethylamino)(oxo)methyl)phenyl)boronic acid; 3-(N,N-Dimethylcarbamoyl)benzeneboronic acid; 3-(Dimethylcarbamoyl)phenylboronic acid; 3-Carbamoylphenylboronic acid dimethylamide; B-[3-[(Dimethylamino)carbonyl]phenyl]boronic acid; 3-(Dimethylaminocarbonyl)benzeneboronic acid; 3-Boronobenzamide, N,N-dimethyl-
EINECS	Contact for details

Quality Control

Our 3-(N,o-Dimethylhydroxylaminocarbonyl)Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.