Description

4-Amino-3-Chlorophenylboronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative, essential as a key synthetic intermediate in modern organic chemistry. Its primary value lies in enabling precise Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in creating complex aromatic and heteroaromatic scaffolds for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the chlorinated aniline moiety and boronate ester functionality allow for targeted structural modifications.
• Material Science & OLED Development: Serves as a precursor for constructing organic semiconductors, light-emitting materials, and charge-transport layers in electronic devices.
• Ligand & Catalyst Design: Employed in the synthesis of specialized ligands for transition metal catalysis and as a precursor for creating novel organoboron catalysts.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and bioconjugates for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Amino-3-Chlorophenylboronic Acid, Pinacol Ester
CAS No.	721960-43-6
Molecular Formula	C12H17BClNO2
Molecular Weight	253.53 g/mol
Synonyms	3-Chloro-4-aminophenylboronic acid pinacol ester; 4-Amino-3-chlorobenzeneboronic acid pinacol ester; (4-Amino-3-chlorophenyl)boronic acid pinacol ester; 2-(4-Amino-3-chlorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3-Chloro-4-aminobenzene-1-boronic acid pinacol ester; 4-Amino-3-chloro-1-benzene boronic acid pinacol ester; PINACOL (4-AMINO-3-CHLOROPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Chlorophenylboronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with every batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.